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Showing 25 / 21760 · page 20/871
Coordination of DNA Metabolism by Replication Protein A
US National Institute of General Medical Sciences · grant
Summary DNA metabolic processes including replication, repair, recombination, and telomere maintenance occur on single-stranded DNA (ssDNA). In each of these complex processes, dozens of proteins function together on the ssDNA template. How…
Posted May 21, 2026
Pre-synaptic events in homologous recombination and maintenance of genomic stability
US · IL NIH · grant
SUMMARY Lesions, breaks, and errors in DNA are drivers of genomic instability. Double-stranded DNA breaks (DSBs) are a particularly severe form of damage and are repaired by the homologous recombination (HR) pathway. On average, ~10 to 50 …
Posted May 21, 2026
Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans
US · IL NIH · grant
Project Summary Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab Americans The incidence of Alzheimer’s disease and related dementia (ADRD) is higher in Black Americans and Hispanics than in non-Hispanic Whites, but data o…
Posted May 21, 2026
Investigating Transplacental Immune Pathways Contributing to Fetal Brain Pathology in Maternal Influenza
US · IL National Institutes of Health (NIH) · grant
Project Summary/Abstract The overarching goal of this application is to identify targetable transplacental immune signaling pathways for optimizing antenatal therapies that improve maternal and offspring health outcomes during seasonal infl…
Posted May 21, 2026
Targeting transcription and translation of the antisense CCCCGG repeat expansion in C9ORF72 ALS/FTD
US National Institute of Neurological Disorders and Stroke · grant
PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) are devastating neurodegenerative diseases with no cure to date. The most common genetic cause of ALS/FTD is a hexanucleotide GGGGCC (G4C2) repeat exp…
Posted May 21, 2026
RFA-PS-21-004: Using Real-time Prescription Data to Support HIV Care and Treatment Adherence in NYC
US National Center for HIVAIDS, Viral Hepatitis, STD, and TB Prevention · grant
Project Summary CDC PS-21-004 This proposed project develops, implements, and evaluates a collaborative “Data-to- Care Rx” model using pharmaceutical insurance claims data to identify persons with HIV in real-time who fail to pick up prescr…
Posted May 21, 2026
Triage of Developmental and Reproductive Toxicants using an In vitro to In Vivo Extrapolation (IVIVE)-Toxicokinetic Computational modeling Application
US National Institute of Environmental Health Sciences · grant
1 PROJECT SUMMARY 2 3 A significant shift in the safety assessment of environmental chemicals is ongoing. This shift includes a reduction, 4 or in some cases elimination, of traditional toxicity testing in animals with the implementation…
Posted May 21, 2026
Immuno/Oncology (IO)
US National Cancer Institute · grant
The Immuno-Oncology Program (IO) established in 2021 unites basic, translational and clinical research scientists from the various disease site programs to address the urgent need to discover novel cancer immunobiologic processes that can b…
Posted May 21, 2026
Remotely-Delivered Cognitive Behavioral Stress Management Effects on Cancer-Accelerated Aging in Older, Distressed Breast Cancer Survivors
US · IL NIH RePORTER · grant
Protocol Synopsis-Brief Summary Study Overview. We will enroll Breast Cancer Survivors (BCS) who completed initial treatment within 3 – 12 months which may or may not have included chemotherapy, are continuing on adjuvant endocrine therapy …
Posted May 21, 2026
Core A: Biospecimen Repository and Pathology
US · IL NIH · NAICS 541714, 621511 · grant
CF1: Biospecimen Repository and Pathology Core ABSTRACT The Biospecimen Repository and Pathology Core (CF1) is designed to provide support to the basic and translational research efforts of the SPORE. CF1 will play a central role in collect…
Posted May 21, 2026
Defining the Role of Aminoacyl-tRNA Synthetases in Human Health and Disease
US · IL NIH · grant
PROJECT ABSTRACT Aminoacyl-tRNA synthetases (ARSs) are a ubiquitously expressed, essential class of enzymes responsible for ligating amino acids to cognate tRNA molecules. Importantly, all 37 loci encoding an ARS have been implicated in dom…
Posted May 21, 2026
All of Us Southern California Consortium (AoUSCC)
US NIH · grant
The overall goal of the All of Us Southern California Consortium, led by the University of California, Irvine, is to engage, recruit, and retain participants from the Southern California population with the goal to participate in the scient…
Posted May 21, 2026
Self-Powered In Vivo Joint Load and Angle Sensing in Total Knee Replacement
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary Total knee arthroplasty (TKA) is one of the most common surgical procedures in all of medicine and despite technical advances, about 10-20% of patients remain dissatisfied with their outcomes and about 9% of patients require…
Posted May 21, 2026
Clinical Research Core
US · FL University of Florida (UF) Older Americans Independence Center (OAIC) · grant
The Clinical Research Core (RC1) is a key resource for the University of Florida (UF) Older Americans Independence Center (OAIC), providing the resources and expertise for conducting research across the spectrum of clinical investigation, i…
Posted May 21, 2026
Primary Cilia: A Novel Signaling Gateway To Neural Circuit Modulation
US · IL NIH · grant
PROJECT SUMMARY Primary cilium, a microtubule based antennae-like organelle, is present in every cortical neuron, and when defective, leads to ciliopathies. A distinguishing feature of ciliopathies is defective neural circuit formation and …
Posted May 21, 2026
DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITY
US · IL NIH · grant
Principal Investigator (Last, First, Middle): Anton, Eva S. PROJECT SUMMARY Radial progenitors serve as an instructive matrix to coordinate the generation and placement of appropriate number and types of neurons in the developing cerebral c…
Posted May 21, 2026
Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior
US · IL NIH · grant
The renewal of the animal protocol “Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior” was approved by the Animal Care and Use Committee on 07/29/2023. Despite the challenges posed by the l…
Posted May 21, 2026
K01 Menstrual Phase, Sexual Dysfunction, mTBI
US · IL National Institute of Neurological Disorders and Stroke (NINDS) · grant
Emerging research suggests that changes in sexual functioning after concussion/mild traumatic brain injury (mTBI) are common in women of reproductive age (18-45years). Findings from my pilot research show that 61.3% of women who sustain a c…
Posted May 21, 2026
The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Project Summary/Abstract This award will promote the development of the applicant who seeks to acquire the skills and knowledge necessary to become an independent physician scientist focused on human rheumatic diseases. The research focus o…
Posted May 21, 2026
Elucidating the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY/ABSTRACT Rotavirus (RV) is the leading cause of viral gastroenteritis in children under the age of 5 globally. Despite the introduction of several WHO-approved vaccines, RV infections still cause 114 million diarrhea episode…
Posted May 21, 2026
Great Plains Center for Agricultural Health
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT – GREAT PLAINS CENTER FOR AGRICULTURAL HEALTH (OVERALL) The Great Plains Center for Agricultural Health conducts research and provides outreach to reduce the burden of injury and illness facing Midwest agricultural…
Posted May 21, 2026
Defining Protective IgGs to Food Allergy
US · IL National Institutes of Health (NIH) · NAICS 541714 · grant
Project Summary/Abstract Approximately 2% of the population of Western country is affected by peanut allergies. Peanut oral immunotherapy OIT has gained traction in the clinic as therapeutic option. However, successful peanut OIT resulting …
Posted May 21, 2026
Harnessing the anti-inflammatory activity of extracellular sialylation of IgG.
US · IL National Institutes of Health · NAICS 541714 · grant
Project Summary/Abstract. Despite the tremendous clinical success of immunotheraputics, little is known regarding IgG2-4 biology relative to IgG1. Our long-term goal is to understand how glycosylation of antibodies regulates, and is regulat…
Posted May 21, 2026
Non-Templated Regulation of IgE Mediated Anaphylaxis
US National Institute of Allergy and Infectious Diseases · grant
Project Summary/Abstract It is not clear why some individuals with allergen-specific IgE suffer from allergies, while others do not. It is likely that multiple factors contribute, including differences in IgE affinity or epitope diversity f…
Posted May 21, 2026
Delivery of a candidate AgTRIOVx malaria vaccine by thermostable microneedle patches
US · IL NIH · NAICS 541714 · grant
ABSTRACT Malaria remains one of the deadliest infectious diseases. Although much progress has been made in the fight against malaria, a highly effective and durable vaccine is not available. New vaccine candidates and improved delivery stra…
Posted May 21, 2026