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Showing 25 / 21760 · page 43/871
Development of a Novel Armored CAR-T Immunotherapeutic for Pancreatic Cancer
US National Cancer Institute · grant
Pancreatic ductal adenocarcinoma (PDAC) represents a major challenge in oncology, the third leading cause of cancer-related death, and a 5-year survival rate of only 11%. The dense, immunosuppressive tumor microenvironment (TME) of PDAC sig…
Posted May 21, 2026
A Multi-Method Study of Momentary Distress Intolerance and Combustible Cigarette Smoking
US National Institute on Drug Abuse · grant
PROJECT SUMMARY Cigarette smoking among adults with emotional distress (i.e. anxiety, depression) is a recognized health disparity. Individuals who smoke cigarettes and experience co-occurring emotional distress (compared to those who do no…
Posted May 21, 2026
Disruption of the circadian clock in lung cancer
US · IL NIH · grant
Project Summary Disruption of the molecular circadian clock is indicative of poor prognosis in non-small cell lung cancers (NSCLCs), but direct evidence for a causal link between circadian clock deregulation and malignancy in human cancer i…
Posted May 21, 2026
TECHNICAL REVIEW AND SUPPORT FOR FY25 NIH GRANT BIOMEDICAL CONSTRUCTION PROJECTS. THIS CONTRACT ENSURES THAT CRITICAL NIH GRANT FUNDED FACILITIES ARE AT THE HIGHEST LEVELS OF SAFETY, EFFICIENCY, AND R
US · IL National Institutes of Health (NIH), Office of Research Infrastructure Programs (ORIP) · grant
The Office of Research Infrastructure Programs (ORIP) leverages the technical expertise resides in the Division of Technical Resources (DTR) within the Office of Research Facilities to coordinate technical review of the design documents and…
Posted May 21, 2026
The Paycheck Protection Program and its Effects on Staffing Patterns and the Outcomes of Residents Living with Dementia
US · IL NIH · grant
Nursing home staff shortages are well known to be an important factor impacting both the quality of care that nursing home residents receive, their health outcomes, and healthcare worker outcomes. Staffing shortages are compounded by limite…
Posted May 21, 2026
Identifying Unmet Needs Driving Disproportionate and Avoidable Nursing Home Placements among Black and Latino Persons Living With Dementia
US National Institute on Aging · grant
PROJECT SUMMARY/ABSTRACT The disproportionate rise in nursing home (NH) use among Black and Latino persons living with dementia (PLWD) reflects the inadequacy of existing programs and policies to support aging in place for the most vulnera…
Posted May 21, 2026
Viral insulin-like peptides and their unique activities on mammalian insulin/IGF-1 system
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY/ABSTRACT In mammals, insulin primarily regulates metabolism while insulin-like growth factor-1 (IGF-1) stimulates growth, proliferation and differentiation. Aberrant production of IGF-1 is connected with different human dise…
Posted May 21, 2026
MYCOBACTERIUM TUBERCULOSIS PROTEOME-WIDE EPITOPE DISCOVERY AND HOST TRANSCRIPTOME-WIDE T CELL PHENOTYPING IN HIGH DISEASE BURDEN POPULATIONS
US National Institute of Allergy and Infectious Diseases · grant
The contractor will apply innovative, highly-multiplexed DNA-barcoded antigen assays to comprehensively discover and validate 100,000s of CD4 T cell epitopes across the entire proteome of Mycobacterium Tuberculosis (Mtb) – together with the…
Posted May 21, 2026
High-resolution, virome-wide infection analysis in type 1 diabetes birth cohorts
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT ABSTRACT/SUMMARY Type 1 Diabetes (T1D) affects >20 million people globally, causing life-long dependency on exogenous insulin and reduced life expectancy. Although the disease has a strong genetic basis, a substantial fraction of ri…
Posted May 21, 2026
Consolidated Basic Cancer Research Program
US National Cancer Institute · grant
PROJECT SUMMARY – OVERALL Rated Exceptional at both the 2013 (impact score, 19) and 2018 (impact score, 14) renewals of the Cancer Center Support Grant (CCSG), and receiving a two-year MERIT extension from the National Cancer Institute (NCI…
Posted May 21, 2026
Inflammatory and Mitochondrial Plasticity in Neuroendocrine Prostate Cancer
US · IL NIH · grant
PROJECT SUMMARY Potent antagonists of androgen and androgen receptor (AR) signaling have revolutionized the treatment of recurrent prostate cancer (PrCa). Despite initial responses, all patients eventually become resistant to treatment, but…
Posted May 21, 2026
Cancer Center Administration
US National Cancer Institute · grant
Cancer Center Administration has continued to play a critical role in supporting the Center’s scientific goals during the last budget cycle of Wistar’s Cancer Center Support Grant (CCSG). Leveraging the Institute’s nimbleness and comprehens…
Posted May 21, 2026
Parkin tumor suppression
US · IL National Institutes of Health · grant
PROJECT SUMMARY The loss of endogenous tumor suppressors is an obligatory step in tumor onset and progression, but the underlying mechanisms are elusive and the breadth of their targets mostly unknown. We have now discovered that Parkin, a …
Posted May 21, 2026
Interspecies Bacterial Signaling to Regulate Salmonella Virulence
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY ABSTRACT Infections by Salmonella present a constant threat to human health in our country and throughout the world. Yet, our progress toward controlling salmonellosis has been largely fruitless; antibiotics are rarely warra…
Posted May 21, 2026
Microbial Metabolites Inhibiting Salmonella Carriage and Disease
US · IL NIH · NAICS 541714 · grant
ABSTRACT Diffusible signal factors (DSFs), long-chain fatty acids with a characteristic cis-2 unsaturation, are produced and used by several genera of gram-negative bacteria as quorum-sensing signals. We have found that the DSF cis-2 hexade…
Posted May 21, 2026
Same-Day Antiretroviral Therapy as a Behavioral Design Intervention to Reduce Stigma in Key Affected Populations
US · IL NIH · grant
Peru's HIV epidemic is concentrated in MSM, where high rates of stigma and discriminaton toward them have undermined treatment outcomes. Despite high diagnostic and linkage rates, MSM have low levels of ART initiation and viral suppression …
Posted May 21, 2026
Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy Intervention
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
HIV transmission continues in low- and middle-income countries (LMIC), especially among key affected populations (KAP) and in settings of high stigma and discrimination. In Malaysia, a LMIC in SE Asia, HIV incidence and mortality is increas…
Posted May 21, 2026
Georgian Implementation Science Fogarty Training Program (GIFT)
US · IL NIH · grant
Despite many available evidence-based interventions (EBIs) to prevent HIV, new infections and mortality in Georgia have increased by 30% and 335%, respectively. Georgia is a LMIC with HIV prevalence of 0.4% and concentrated in key at-risk p…
Posted May 21, 2026
Prison Interventions and HIV Prevention Collaboration
US · IL NIH · grant
Eastern Europe and Central Asia (EECA) have among the highest (5 of the top 10) incarceration rates worldwide, with staggering numbers of people who inject drugs (PWID), mostly with opioid use disorder (OUD: 82%) and HIV (PWH: 18%). The HIV…
Posted May 21, 2026
Malaysian Implementation Science Training (MIST) Program in HIV
US · IL NIH · grant
Despite an array of evidence-based interventions (EBIs) to address HIV - and the 95/95/95 strategy the HIV epidemic in Malaysia and Indonesia remains volatile. Malaysia's rapidly expanding HIV epidemic is the fifth largest in the Asia-Pacif…
Posted May 21, 2026
Innovations in Implementing Decentralized HIV Services in Peru
US · IL · Lima National Institutes of Health (NIH) · grant
Despite successes in diagnosing and initiating antiretroviral therapy (ART) in people with HIV (PWH) in Peru, a LMIC with an HIV epidemic concentrated in key at-risk populations, the implementation gap is highest for retention in care (RIC)…
Posted May 21, 2026
Integrating Addiction and Infectious Diseases Services into Primary Care in Rural Settings
US National Institute on Drug Abuse · grant
Abstract The US strategy to End the HIV Epidemic calls for expanded prevention of new infections and more effective responses to HIV outbreaks. These outbreaks often occur in counties and states that share a disproportional burden of HIV, b…
Posted May 21, 2026
Expanding Medication Assisted Therapies in Central Asia
US National Institute on Drug Abuse · grant
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners. Scaling up opioid agonist therapies (OAT) in CA is the most cost-effective strate…
Posted May 21, 2026
North American AIDS Cohorts on Collaboration and Design (NAACCORD)
US · IL NIH · grant
(no more than 30 lines) The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) has represented Region 1 of the leDEA initiative since 2006. The >20 single and multi-site clinical and classical epidemiologic HIV coho…
Posted May 21, 2026
The role of Nrf2 in beta cell expansion during pregnancy
US · IL National Institutes of Health · NAICS 541714 · grant
Summary The late stages of the mammalian pregnancy are accompanied with increased insulin resistance due to the increased glucose demand of the growing fetus. Therefore, as a compensatory response, in order to maintain the maternal normal b…
Posted May 21, 2026