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Showing 25 / 21760 · page 45/871
Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders
US Veterans Affairs · grant
The ileal apical sodium-dependent bile acid transporter (ASBT) is crucial for the enterohepatic circulation of bile acids and plays a key role in maintaining bile acid, lipid, and cholesterol balance. Emerging evidence suggests that ASBT is…
Posted May 21, 2026
Machine learning of biomolecular interactions and the human signaling networks they comprise
US National Institute of General Medical Sciences · grant
My lab will use machine learning to build physically-grounded models of biomolecules and their interactions and apply these models at proteome (genome) scale to address basic questions in the systems biology of human signaling. On the model…
Posted May 21, 2026
Fast and slow prediction of stable and transient protein-protein interactions
US National Library of Medicine · grant
Protein-protein interactions (PPIs) underpin processes ranging from transduction of signaling networks to maintenance of cellular structure. Identifying new human PPIs may uncover interactions targetable by PPI- modulating drugs, while iden…
Posted May 21, 2026
Developing a redox-mediated single NP detection for bioconjugate analysis.
US National Institute of General Medical Sciences · grant
Although immunoassays are a critical part of bioanalytical chemistry, the rapid and selective analysis of biomolecules continues to be a complicated aspect of biomedical research. The long-term goal is to develop single-entity electrochemis…
Posted May 21, 2026
BLR&D Research Career Scientist Award
US Veterans Affairs · grant
Bile duct epithelial cells (i.e., cholangiocytes) are the target cells in cholangiopathies such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and cholangiocarcinoma (CCA), which are diseases characterized by th…
Posted May 21, 2026
IND-enabling studies for eCD4-Ig as a long-acting recombinant protein therapeutic
US · IL NIH · NAICS 541714 · small business · grant
ABSTRACT This FastTrack SBIR grant will support pre-clinical IND-enabling studies for recombinant eCD4-Ig protein, ahead of a first-in-human (FIH) Phase 1 clinical trial. eCD4-Ig is an antibody-like therapeutic for HIV consisting of parts …
Posted May 21, 2026
Process development for manufacturing eCD4-Ig
US · IL NIH · grant
ABSTRACT eCD4-Ig is an antibody-like therapeutic for HIV that was constructed by fusing CD4 domains 1 and 2, and an HIV coreceptor-mimetic sulfopeptide, to the N- and C-termini of the constant Fc region of an antibody. eCD4-Ig will join an…
Posted May 21, 2026
SARS-CoV-2 vaccines based on RBDs with engineered glycosylation sites
US National Institute of Allergy and Infectious Diseases · grant
 We are developing vaccine antigens for SARS-CoV-2 that focus the antibody response onto neutralizing epitopes in the receptor binding domain (RBD) of the viral Spike (S) protein. Booster antigens derived from variants of SARS-CoV-2 would e…
Posted May 21, 2026
Developing shared medical appointments for informal caregivers of Alzheimer’s and Dementia patients to improve knowledge, communication, and advanced planning
US · IL NIH RePORTER · grant
Project Summary The prevalence of Alzheimer's Disease and related Dementias (ADRD) is expected to triple by 2060, affecting about 14 million Americans. As ADRD progresses, symptoms worsen, putting informal caregivers (ICs) in charge of tend…
Posted May 21, 2026
A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx
US National Institute of Mental Health · grant
PROJECT SUMMARY / ABSTRACT In response to PAR-20-237, “community interventions to address the consequences of the COVID-19 pandemic among health disparity and vulnerable populations,” we propose to study a parent-focused mentalizing interve…
Posted May 21, 2026
Enhancing PTSD Treatment Outcomes by Improving Patient-Provider Communication
US · MA · Boston National Institutes of Health (NIH) · grant
Project Summary/Abstract Posttraumatic stress disorder (PTSD) is a debilitating condition with deleterious effects on individuals and society. Evidence-based treatments for PTSD are available, including cognitive processing therapy (CPT) an…
Posted May 21, 2026
Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging
US National Institute of General Medical Sciences · grant
Project Summary Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging Many amyloidogenic peptides are implicated in diseases ranging from Alzheimer’s to diabetes to cardiomyopathy. Chaperone proteins such as HSP27 and αB-…
Posted May 21, 2026
Mechanisms and Impact of Pregnancy-Induced Adaptations in Pelvic Floor Muscles
US · IL NIH · grant
PROJECT SUMMARY Our proposal exemplifies the NIH vision that the multidisciplinary approach to clinical care and research is the most fruitful paradigm for the development of significant advancements within a specific field. While it is unf…
Posted May 21, 2026
Regenerative biomaterial for combating genitourinary syndrome of menopause
US · IL NIH · NAICS 541714 · grant
Project Summary Genitourinary syndrome of menopause (GSM) is an extremely prevalent condition consequent to the hypoestrogenic changes in the genitourinary tract that affects up to 85% of perimenopausal and menopausal women. Major symptoms …
Posted May 21, 2026
MDS-associated U2AF1 mutations induce natural killer cell dysfunction
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Therapeutic approaches that harness the immune system to target tumors are revolutionizing the cancer treatment field. Natural Killer (NK) Cells are innate lymphocytes that regulate inflammatory and immune responses…
Posted May 21, 2026
MDS-Associated Spliceosome Mutations Regulate Host Defense
US · IL NIH · grant
ABSTRACT Myelodysplastic Syndrome (MDS) is a hematopoietic stem cell disorder characterized by myeloid cell differentiation defects and dysplastic blood cell production. The majority of MDS patients die of disease related causes, with infec…
Posted May 21, 2026
The role of alpha-adrenergic vasoconstriction on blood flow to exercising skeletal muscle in patients with heart failure with preserved ejection fraction
US · IL NIH · grant
Heart Failure (HF) is a leading cause of hospitalization and mortality among older adults in America1. Veterans, in particular, appear to have a greater risk of developing HF than non-Veterans and hospital readmission rates of Veterans are …
Posted May 21, 2026
ErythroMer: Nanoscale BioSynthetic Red Cell Substitute
US National Heart Lung and Blood Institute · grant
Research Summary/Abstract ErythroMer (EM) is a novel biosynthetic blood substitute developed to address the critically unmet need for emergency transfusion in situations where the use of banked red blood cells (RBCs) are either not availabl…
Posted May 21, 2026
Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT The objectives of this K08 proposal are to foster the development of critical scientific and professional skills that will allow the candidate, Dr. Mona Alotaibi, to advance toward her goal of becoming an independen…
Posted May 21, 2026
Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
US · IL NIH · grant
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports, military service, and physical violence. These impacts can confer risk for Alzheimer’s disease (AD) and related dementias (ADRD) including ch…
Posted May 21, 2026
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project II
US · IL National Institute of Neurological Disorders and Stroke (NINDS) / National Institutes of Health (NIH) · grant
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease diagnosed postmortem in people exposed to repetitive head impacts (RHI) from football and other contact sports. NINDS consensus research diagnostic criteria for the clini…
Posted May 21, 2026
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
US · IL NIH · grant
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may increase risk for later-life cognitive decline and neuropsyc…
Posted May 21, 2026
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric Symptoms
US · IL NIH · NAICS 541715 · grant
Each year, millions of Americans are exposed to repetitive head impacts (RHI) through contact sport participation and may be at risk for chronic traumatic encephalopathy (CTE). The clinical presentation of CTE is ill-defined and includes de…
Posted May 21, 2026
Children's Oncology Group Statistics and Data Center
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Since the introduction of chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The overall 5-year survival rate for childhood cancers, many…
Posted May 21, 2026
Children's Oncology Group
US · IL National Cancer Institute (NCI) · grant
PROJECT SUMMARY Since the introduction of combination chemotherapy for the treatment of childhood leukemia more than 60 years ago, the prognosis of childhood cancer has improved dramatically. The 5-year survival rate for childhood cancers, …
Posted May 21, 2026