Live opportunities

21,760 contracts

🏛Federal 🗽State 🏞County 🏙City 🎓Schools 🚇Districts 📚Universities
Showing 25 / 21760 · page 52/871
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
US · IL NIH · grant
PROJECT SUMMARY Myocardial infarction (MI) and coronary artery disease (CAD) are the leading causes of death in Western societies. Individuals with CAD are typically asymptomatic, with the first manifestations often being major adverse car…
Posted May 21, 2026
Genetic and Gut Microbial Regulation of Indole-3 Propionate in Metabolic Disease
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
PROJECT SUMMARY Metabolic diseases, such as obesity and type 2 diabetes (T2D), are characterized by perturbations of glucose tolerance, pancreatic beta cell function, energy imbalance, appetite regulation, and other unknown pathways. Clini…
Posted May 21, 2026
Modulation of network dynamics across mood states using closed-loop deep brain stimulation for depression
US National Institute of Mental Health · grant
Major Depressive Disorder (MDD) is a prevalent and debilitating disorder, where one-third of this population is treatment-resistant. Depression is characterized by cognitive dysfunction, including deficits in cognitive control, defined as f…
Posted May 21, 2026
Nuclear moonlighting of arsenic metabolic enzymes and reprogramming-resistant epimutations
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to understand how environmental chemicals trigger a deregulation of the epigenome that can resist epigenetic reprogramming in germ cells and therefore ca…
Posted May 21, 2026
Role of epigenetic crosstalks in directing locus sensitivity to arsenic
US National Institute of Environmental Health Sciences · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to understand what make some genomic loci more susceptible than others to environmental chemical perturbation. Using inorganic arsenic (iAs) as a model e…
Posted May 21, 2026
Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunction
US National Institute on Alcohol Abuse and Alcoholism · grant
PROJECT SUMMARY The overarching goal of the research presented in this application is to dissect the genetic, epigenetic, and metabolic programs that encode and transmit a memory of environmental exposure for several generations. In that c…
Posted May 21, 2026
The Howard University Expanding Research in Alzheimer's Disease and Related Dementias Postbaccalaureate Research Education Program (HU-ERA-PREP)
US National Institute on Aging · grant
The Howard University-Enhancing Research in Alzheimer’s disease (HU-ERA) program is a two-year postbaccalaureate research training initiative designed to prepare recent college graduates for successful entry into advanced research careers i…
Posted May 21, 2026
Nanoreactor beads for POC TB resistance testing
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Rapid and sensitive point of care tests that can detect all forms of drug resistance in tuberculosis (TB) are urgently needed to address the rise of drug resistance. We propose to develop a novel mutation detection system that use…
Posted May 21, 2026
Resources, Workforce Development, and Animal Models for the Rutgers RBL
US National Institute of Allergy and Infectious Diseases · grant
Overall ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) therapeutic, pathogenesis, and diagnostic research on high threat biological agents with …
Posted May 21, 2026
Point of care detection of fluroquinolone, bedaquiline and linezolid resistant Mycobacterium tuberculosis for rapid treatment decisions.
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Rapid and sensitive point of care tests that can detect all forms of drug resistance are urgently needed to enable appropriate treatment for TB. Molecular drug susceptibility tests (mDSTs) which use nucleic acid amplification tech…
Posted May 21, 2026
Bacteria and Host in TB Transmission
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Halting tuberculosis (TB) transmission will be most efficiently achieved by focusing control efforts on sites of high transmission and by developing new drugs and vaccines that target bacterial transmission. We hypothesize that ho…
Posted May 21, 2026
Unraveling the spectrum of intrabacterial amide hydrolysis to develop new classes of pyrazinoic acid prodrugs against pyrazinamide resistant Mycobacterium tuberculosis
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Mycobacterium tuberculosis (Mtb) infection is a global health pandemic claiming 1.5 million lives each year. Current tuberculosis (TB) therapies are challenged by drug resistance, characterized by mutations that render approved dr…
Posted May 21, 2026
Lead Optimization and Preclinical Development of a small molecule inhibitor of M. avium KasA
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT. Non-tuberculous mycobacteria (NTM) constitute a major threat to global health with over 200,000 annual cases in the United States alone. Mycobacterium avium complex (MAC) infections are the most common cause of NTM pulmonary dise…
Posted May 21, 2026
Near patient detection of pathogenic candida species directly from blood and urine for rapid treatment response
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT Fungal species are among the most common causes of nosocomial bloodstream and invasive infections in immunocompromised hosts. Mortality from candidemia can be very high, ranging from 20-40%. The global emergence of virulent multid…
Posted May 21, 2026
Bacterial and Host Heterogeneity in TB latency, persistence and progression
US National Institute of Allergy and Infectious Diseases · grant
ABSTRACT - OVERALL Until recently, Tuberculosis (TB) has been viewed as a disease that progresses over several discrete stages, principally consisting of a period of infection followed by either active TB disease or a latent state with the …
Posted May 21, 2026
The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Low-resource settings have a high burden of Neisseria gonorrhoeae infection, but insufficient laboratory infrastructure for diagnostic tests and antimicrobial susceptibility determination, leading to syndromic management, wh…
Posted May 21, 2026
RFA-DP-23-001, Simulation Model of Interventions Linking Evidence to SDOH (SMILES)
US · IL NIH RePORTER · NAICS 541715, 541511 · grant
PROJECT SUMMARY/ABSTRACT To support the Centers for Disease Control and Prevention (CDC) and states and communities in identifying programs, policies, or practices (PPP) that can reduce the ever-widening gaps in chronic disease incidence an…
Posted May 21, 2026
The Impact of Soluble ST2 on Lung Injury Onset and Resolution
US National Heart Lung and Blood Institute · grant
Project Summary Candidate: Jehan Alladina, MD is a physician-scientist at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS). Her post-doctoral research interrogated type 2 (T2) immune pathways in allergic asthma. Buildin…
Posted May 21, 2026
The Molecular and Cellular Basis of the Sleep Homeostat
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Understanding why we sleep remains one of the most enduring mysteries in science. Nearly every organism examined, even jellyfish that lack a centralized nervous system, exhibits a restorative sleep-like state. While asleep, …
Posted May 21, 2026
Best Practices to Return Results About Pesticide Exposures in Family Child Care Homes
US National Institute of Environmental Health Sciences · grant
Abstract The goal of this study is to develop best practices for returning results to family child care home (FCCH) directors about pesticides present in their facilities. Best practices will be defined as activities that maximize comprehen…
Posted May 21, 2026
MUSICA - MUsic and Speech Induced Cerebral Activation
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract Severe traumatic brain injury (TBI) has a high mortality, largely driven by the early withdrawal of life-sustaining therapies during hospitalization. This critical decision is influenced by whether patients remain u…
Posted May 21, 2026
Metabolomic interrogation of gut mechanosensing in Drosophila
US National Institute on Aging · grant
Project description Gut epithelium is the principal site in which neural, immune, microbial and dietary factors interact. These multi-system interactions critically regulate whole-body physiology including metabolism, immunity, and neurodeg…
Posted May 21, 2026
Soluble Epoxide Hydrolase Inhibitor GSK2256294 for Acute Ischemic Stroke
US National Institute of Neurological Disorders and Stroke · grant
Project Summary The proposed translational studies will determine the cereroprotective efficacy of GSK2256294, an FDA- approved soluble epoxide hydrolase (sEH) inhibitor. Inhibition of sEH increases the endogenous levels of its substrate ep…
Posted May 21, 2026
Role of GPR39 in Aging-Related Vascular Cognitive Impairment (VCI)
US National Institute on Aging · grant
Summary Abstract Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease. The most common cause of VCI is cerebral small vessel disease (SVD). The mechanisms underlying SVD are poorly unders…
Posted May 21, 2026
Training in Translational Science and Cardiovascular Research
US National Heart Lung and Blood Institute · grant
This proposal seeks support for a well-established training program in translational cardiovascular research for MD and PhD postdoctoral fellows at Oregon Health & Science University (OHSU). The training program has a long history of traini…
Posted May 21, 2026