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Showing 25 / 21760 · page 9/871
CALIBER Dissemination and Community Engagement Core
US National Institute on Alcohol Abuse and Alcoholism · grant
The Dissemination and Community Engagement (DICE) Core advances the scientific mission of the CALIBER Center by closing the gap between research and practice through engaging with persons highly impacted by unhealthy alcohol use and HIV and…
Posted May 21, 2026
Investigating the RNA-Regulatory Activities of the RNA Exosome during Human Motor Neuron Differentiation
US · IL NIH · grant
Project Summary: Accurate stem cell differentiation requires precise gene regulation at both the transcriptional and post- transcriptional levels. While the transcriptional activation networks governing cellular differentiation are well cha…
Posted May 21, 2026
HIV reverse transcriptase structure, function, inhibition, and roles in viral assembly and maturation
US · IL NIH · grant
Project Abstract HIV remains a key health challenge, with fundamental aspects of the viral replication machinery remaining poorly understood. Building on our extensive studies of HIV-1 reverse transcriptase (RT) structure and function, we p…
Posted May 21, 2026
Methods for anterograde tracing of active circuits
US · IL NIH · grant
Project Summary A central yet unrealized goal of modern neuroscience is to map all the neural circuits within the brain and the changes that occur during development, learning, aging, and in disease states. Towards this end, we recently dev…
Posted May 21, 2026
Applying digital phenotypes and epigenetics to understand clinical outcomes in acute hypoxemic respiratory failure without acute respiratory distress syndrome (NAHRF)
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Each year approximately 1 million adults receive invasive mechanical ventilation in the United States for acute hypoxemic respiratory failure (AHRF), and 30-40% of these patients die in the hospital. Most research has focuse…
Posted May 21, 2026
Computational Feature Profiling and Modeling for Prostate Cancer Detection and Risk Stratification
US · IL National Institutes of Health (NIH) · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Prostate cancer is the most common and second deadliest non-skin cancer in American men, accounting for 26% of new cancer diagnoses and 9% of cancer deaths in men. Active surveillance, radical prostatectomy and radi…
Posted May 21, 2026
Hox gene regulation of body size and asexual reproduction underlie regenerative abilities
US · IL NIH · grant
Abstract The ability of certain animals to regenerate their cells and tissues has long been a subject of interest for biologists due to its relevance to animal development and regenerative medicine. However, we still don't fully understand…
Posted May 21, 2026
Effect of WASH interventions on population resilience to climate-driven enteric pathogen transmission along a gradient of socio-economic position
US National Institutes of Health · grant
Background: Most of rural Bangladesh is situated in the Ganges-Brahmaputra-Meghna river basin which is home to over 618 million people and represents one of the most climate-sensitive populations in the world. Living in the basin exposes th…
Posted May 21, 2026
Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settings
US · IL NIH · grant
Enteric pathogen infections cause an immense disease burden among children in low-resource settings. Understanding pathogen-specific transmission in high burden populations, and whether transmission is reduced through environmental interven…
Posted May 21, 2026
Seroepidemiology of trachoma for the elimination endgame
US · IL NIH · NAICS 541715 · grant
Trachoma, caused by ocular Chlamydia trachomatis infection, is the leading infectious cause of blindness worldwide and been targeted for global elimination as a public health problem by 2030. As we approach the endgame, there is broad inter…
Posted May 21, 2026
Effect of WASH interventions on population resilience to seasonally-driven enteric pathogen transmission along a gradient of socio-economic position
US · IL NIH · grant
Background: Most of rural Bangladesh is situated in the Ganges-Brahmaputra-Meghna river basin which is home to over 618 million people and represents one of the most vulnerable populations in the world to extreme weather events. Living in t…
Posted May 21, 2026
Enteric Pathogen Force of Infection among Children using Serology
US · IL NIH · NAICS 541714 · grant
Enteric pathogen infections are a leading cause of the global disease burden, with the largest burden among children in low-resource settings. Stool-based PCR methods have dramatically improved our ability to measure enteric infections, but…
Posted May 21, 2026
Transformative rat models to study sex differences in disease
US NIH Office of the Director · grant
Project Summary The long-term objectives are to develop and validate rat models of disease that allow investigators to measure the differential effects of XX and XY sex chromosomes that protect from or exacerbate disease. Most human diseas…
Posted May 21, 2026
Angiotensin-(1-7) and Hypothalamic control of blood pressure
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Obesity is a global epidemic that is associated with excessive central sympathetic outflow to cardiovascular end organs to elevate blood pressure and predispose to hypertension. Accumulating evidence from our laboratory sugg…
Posted May 21, 2026
Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
US · IL NIH · grant
PROJECT SUMMARY Obesity is a global epidemic that is associated with sympathetic overactivation, endothelial dysfunction, and insulin resistance; all of which can contribute to hypertension development. Despite well-established clinical ass…
Posted May 21, 2026
Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition
US · IL NIH · NAICS 541715 · grant
Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that disproportionately affects women, particularly those from underserved populations who face higher rates of trauma exposure. PTSD is associated with trauma-r…
Posted May 21, 2026
Medical countermeasures to chlorine exposure based on GABA(A) receptor targeting
US National Institute of Environmental Health Sciences · grant
The proposed research will demonstrate the therapeutic efficacy of one or more gamma aminobutyric acid type A receptor (GABAAR) modulators in reducing acute lung injury (ALI) caused by inhaled chlorine. The research is significant because i…
Posted May 21, 2026
Longitudinal EEG and Environmental Trajectories Leading to ADHD and Disruptive Behaviors from Infancy to Preschool
US · IL NIH · grant
Project Summary Attention deficit hyperactivity disorder (ADHD) and disruptive behaviors (DBs) affect up to 9% of children. Under-diagnosis and under-treatment of ADHD and DBs disproportionately affect children with socioeconomic stress and…
Posted May 21, 2026
Elucidating the role of hepatic ketogenesis in pancreatic cancer cachexia and recovery
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY/ABSTRACT 80% of patients with Pancreatic Ductal Adenocarcinoma (PDAC) develop cachexia, which results in dispropor- tionate skeletal muscle mass loss, relative to caloric deficits. Cachexia causes functional impairment and i…
Posted May 21, 2026
Targeting insomnia to improve outcomes in adults with problematic cannabis use
US National Institute on Drug Abuse · grant
Cannabis use, heavy cannabis use, and cannabis-related problems are becoming increasingly common in the United States. Among those who use cannabis regularly, significant insomnia is common. For example, our data from 800 patients seeking m…
Posted May 21, 2026
Structural characterization of the HIV-2 capsid lattice
US · IL National Institutes of Health (NIH) · grant
Project Summary/Abstract Human retroviral infections (i.e., human immunodeficiency virus type 1, HIV-1; and HIV type 2, HIV-2) impact a combined 38 million people worldwide and result in at least 680,000 deaths per year. Despite advancement…
Posted May 21, 2026
Mechanisms that Couple Chromatin Modifications to Transcription
US National Institute of General Medical Sciences · grant
Project Summary The goal of this research program is to elucidate the proteins and mechanisms that regulate transcription within the context of chromatin, a process critical to every eukaryotic cell. Nucleosomes pose barriers to RNA polymer…
Posted May 21, 2026
Toward efficient performance for deep learning on medical imaging
US National Heart Lung and Blood Institute · grant
Project Summary / Abstract Objective — The goal of this renewal is to continue developing and optimizing novel deep learning (DL) and related methods to improve diagnosis and clinical decision-making for congenital heart disease (CHD). Nota…
Posted May 21, 2026
Structure and Function of Integrins in the Kidney
US · IL NIH · grant
Abstract The stoichiometric cis association of the tetraspanin CD151 with podocyte integrin α3β1 is essential for stabilizing α3β1 in an active ligand-binding conformation, thus maintaining the integrity of the glomerular filtration barrier…
Posted May 21, 2026
Platelet alphaIIbbeta3 activation and its therapeutic targeting
US · IL NIH · grant
Abstract Platelet integrin αIIbβ3 plays a central and nonredundant role in hemostasis and thrombosis. It is normally kept in a default inactive conformation in resting free-flowing platelets in the circulation. Despite extensive efforts, it…
Posted May 21, 2026