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Leveraging inter-individual differences in walking pain and impairment to elucidate whole-person mechanisms of knee osteoarthritis
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

Project Summary/Abstract Knee osteoarthritis (OA) is a common and debilitating condition, affecting millions in the United States of America. From 1990 to 2020, OA ranked as the 14th highest cause of

Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal Approach
National Institute of Neurological Disorders and Stroke
GRANT

Project Summary Traumatic brain injury (TBI) is a significant health care problem, affecting over 2.5 million people in the United States annually. Most cases are classified as mild or concussive TBI,

Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal Approach
National Institute of Neurological Disorders and Stroke
GRANT

Project Summary Traumatic brain injury (TBI) is a significant health care problem, affecting over 2.5 million people in the United States annually. Most cases are classified as mild or concussive TBI,

Absolute Brain Thermography using Multinuclear MRI
National Institute of Biomedical Imaging and Bioengineering
GRANT

PROJECT SUMMARY Stroke is the leading cause of disability, the second leading cause of dementia, and the second leading cause of death worldwide, affecting nearly 800,000 patients per annum in the U.

Absolute Brain Thermography using Multinuclear MRI
National Institute of Biomedical Imaging and Bioengineering
GRANT

PROJECT SUMMARY Stroke is the leading cause of disability, the second leading cause of dementia, and the second leading cause of death worldwide, affecting nearly 800,000 patients per annum in the U.

Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

Project Summary In osteoarthritis (OA), intra-articular inflammation is a key mediator of joint destruction and chronic joint pain. Unfortunately, current strategies to control joint inflammation hav

Treatment of Knee Osteoarthritis via Intra-articular Delivery of an Immunosuppressive Enzyme
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

Project Summary In osteoarthritis (OA), intra-articular inflammation is a key mediator of joint destruction and chronic joint pain. Unfortunately, current strategies to control joint inflammation hav

Innervation of the knee and TMJ
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

The over-arching goal for the RE-JOIN Consortium is to define how the neurons that mediate chronic joint pain innervate different articular and peri-articular tissues, with a focus on the knee and tem

STepped Exercise Program for Knee Osteoarthritis: The STEP-KOA Study
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

Knee osteoarthritis (OA) is a leading cause of pain and disability. Exercise is a first-line component of care for knee OA. However, the majority of individuals with knee OA are inactive, and exercise

Precision Medicine Approach to Exercise-Based Interventions for Veterans with Knee Osteoarthritis
Veterans Affairs
GRANT

Background: Knee osteoarthritis (OA) is a leading cause of pain and disability, and Veterans have markedly greater rates than non-Veterans. Exercise is a core component of care for knee OA, associated

Project 3- FXPOI: Mechanisms and Modifiers
Eunice Kennedy Shriver National Institute of Child Health and Human Development
GRANT

Abstract - Project 3 Up to an estimated 1 in 151 women carry a fragile X premutation (PM) allele, impacting over one million women in the US. In addition to being at risk for having a child with fragi

Mechanisms of Gait and Balance Impairment in Progressive Supranuclear Palsy
National Institute of Neurological Disorders and Stroke
GRANT

PROJECT SUMMARY/ABSTRACT Progressive supranuclear palsy (PSP) is a fatal, progressive, incurable neurodegenerative tauopathy. Falls resulting from gait and balance impairments are a cardinal feature o

Psychosocial stress and its relation to maternal and infant outcomes among women with disabilities
Eunice Kennedy Shriver National Institute of Child Health and Human Development
GRANT

Women with disabilities are increasingly becoming pregnant, and may be as likely to become pregnant as women without disabilities. Growing research suggests pregnancy in women with disability is assoc

PREVENTABLE Administrative and Trial Management
National Institute on Aging
GRANT

Duke Clinical Research Institute (DCRI) and Wake Forest School of Medicine (WFSM) will combine their world-renowned expertise and exceptional resources to lead the PREVENTABLE trial. This trial will d

Personalized Closed-loop Theta Burst Stimulation for Treatment of Depression
National Institute of Mental Health
GRANT

PROJECT SUMMARY Depressive disorders are increasingly prevalent in modern societies. Clinical depression is the leading cause of disability worldwide and an underlying condition for two-thirds of suic

PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)
National Institute of Neurological Disorders and Stroke
GRANT

PROJECT SUMMARY . Acute ischemic stroke is the leading cause of disability in the United States and the second-leading cause of death worldwide. AIS that involves a major cervical or cerebral artery i

The role of EZH1 in neuronal differentiation and neurological disorders
National Institute of Neurological Disorders and Stroke
GRANT

PROJECT SUMMARY Intellectual disabilities (ID) are lifelong conditions caused by neurodevelopmental errors. We recently identified gain and loss of function (GOF and LOF) mutations in the chromatin mo

Travel: International Conference on Complex and Differential Geometry
NSF
GRANT

The International Conference on Complex and Differential Geometry (ICCDG) will take place at the International Centre for Theoretical Physics (ICTP) in Trieste, Italy, on May 25–29, 2026. The conferen

ERI: Engineering a Hybrid Wearable System to Study High-Risk Postures and Low Back Pain-Related Disability
NSF
GRANT

Low back pain is the most common cause of disability worldwide and leads to missed workdays and high healthcare costs. It is often treated after pain begins, using methods like medication and surgery.

CAREER: Chronically Stable, High-Precision, Multimodal Bioelectronic Platform for Longitudinal In-Situ Interrogation of Peripheral Nerve Injury
NSF
GRANT

Peripheral nerve injuries (PNI) are a leading cause of chronic disability that affects millions of people in the U.S. Understanding long term effects of PNI is challenging because most diagnostic too

CAREER: Understanding Traumatic Brain Injury Through Cross Species Brain Biomechanics
NSF
GRANT

This Faculty Early Career Development Program (CAREER) award supports a research and education program that improves the understanding of how head impacts and traumatic events cause brain injury in hu

An Artificial Intelligence Foundation Model for Functional Neuroimaging: Personalized Prediction, Treatment Stratification, and Biotype Discovery in Major Depressive Disorder
National Institute of Mental Health
GRANT

PROJECT SUMMARY Major depressive disorder (MDD) is a leading cause of disability, with substantial individual and societal costs. The heterogeneity of MDD and the lack of predictive tools for individu

End Diagnostic Overshadowing: Addressing Ableism in the Healthcare Context
Eunice Kennedy Shriver National Institute of Child Health and Human Development
GRANT

Through our End Diagnostic Overshadowing: Addressing manifestations of ableism in the healthcare context program we aim to identify and create understanding of mechanisms underlying diagnostic oversha

Molecular Determinants of Pigmentation (MDoP)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

“Molecular Determinants of Pigmentation (mDoP)” study aims to identify and characterize new genes and proteins essential for pigmentation development, melanosomes transportation, function and maintena

Molecular Determinants of Pigmentation (MDoP)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
GRANT

“Molecular Determinants of Pigmentation (mDoP)” study aims to identify and characterize new genes and proteins essential for pigmentation development, melanosomes transportation, function and maintena

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