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Showing 25 / 21760 · page 30/871
Determinants of cardioprotection by circulating prohibitin-1 during sepsis
US · IL NIH · grant
ABSTRACT: Sepsis is a dangerous hyper-inflammatory condition that carries a mortality rate of 25% for uncomplicated cases and rises to 80% for patients who develop multiple organ dysfunction syndrome (MODS). No specific therapies for MODS e…
Posted May 21, 2026
Loyola-Ukrainian Catholic University International Bioethics Research Training Program
US John E. Fogarty International Center for Advanced Study in the Health Sciences · grant
Project Summary/Abstract The Loyola University Chicago-Ukrainian Catholic University (LUC-UCU) Doctoral and Post- Doctoral Bioethics Training Program will provide advanced doctoral-level education in research ethics in English to Ukrainian …
Posted May 21, 2026
Patterns in Women's Unmet Sexual and Reproductive Healthcare Needs Over the Life Course
US Eunice Kennedy Shriver National Institute of Child Health and Human Development · grant
ABSTRACT Unmet sexual and reproductive healthcare (SRH) needs are a significant problem in the United States and are associated with a broad spectrum of negative sexual and reproductive health outcomes. Consequently, it is essential to und…
Posted May 21, 2026
Optimizing the Implementation of Whole Health Coaching for Veterans with COPD
US · IL NIH · grant
Background: VHA has committed to building the Whole Health system of care in which Veterans are empowered and equipped to pursue their best possible vision of health and well-being through self-care, conventional clinical care, and compleme…
Posted May 21, 2026
Integrating Next Generation Simulator Training and Operating Room Performance Assessment into Orthopedic Residency Programs
US · IL NIH · grant
Project Summary/Abstract The long-term goal of this research is to improve patient safety by establishing simulator training and evaluation of surgical skills as essential components of orthopedic residency programs. Many orthopaedic surge…
Posted May 21, 2026
CK20-004, Duke-UNC Prevention Epicenter Program for Protecting Patients from Infections, Antibiotics Resistance and Other Adverse Events
US National Center for Emerging and Zoonotic Infectious Diseases · grant
Project Summary Healthcare-associated infections (HAIs) and antimicrobial resistance (AR) lead to adverse patient outcomes, including increased mortality, morbidity, and length of hospitalization. While progress in prevention is occurring, …
Posted May 21, 2026
An infection prevention dilemma: should we place patients with C. difficile colonization on contact precautions?
US · IL NIH · grant
Project Summary - Clostridioides difficile is a leading cause of infectious diarrhea and the most common cause of healthcare-associated infection (HAIs) in the US, resulting in >450,000 infections and 29,000 deaths annually. In fact, C. dif…
Posted May 21, 2026
Project 3: Film Formulation, PK/PD and Safety Studies of ZB-06
US · PA National Institutes of Health (NIH) · grant
PROJECT 3 - ABSTRACT The primary objectives of Project 3 are to optimize the vaginal film delivery system for the Human Contraception Antibody (HCA) and to perform assays to assess PK/PD and safety endpoints in vaginal samples from women in…
Posted May 21, 2026
Circuit basis of social behavior decision-making in a subcortical network
US National Institute of Neurological Disorders and Stroke · grant
Project Summary/Abstract This proposal responds to an FOA (RFA-NS-18-030) calling for 1) “novel approaches to understand neural circuitry associated with well-defined social behaviors;” 2) Distributed circuits that contribute to the coordi…
Posted May 21, 2026
Imaging neuromodulation in the brain
US · IL NIH · grant
Addiction involves brain systems mediating internal states of motivation, arousal and reward, as well as emotions. Such internal states influence goal-directed behaviors and decision-making. A common feature of such internal states is their…
Posted May 21, 2026
Advanced Mass Spectrometry Facility
US · IL NIH · grant
Historically the facility has supported on the order of 40 PIs each year involved with around 70 annual report level projects with around two-thirds of these projects coming from the NIDDK. Although useful metrics for some things, the PI-…
Posted May 21, 2026
SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A
US National Institute of Biomedical Imaging and Bioengineering · grant
Cell-based therapies, where naturally or artificially engineered cells secreting therapeutic proteins are grafted onto the body to act as biological drug factories, are an attractive approach for long-term treatment of chronic diseases such…
Posted May 21, 2026
Combinatorial and computational design of bnAb mRNA vaccines for HIV
US National Institute of Allergy and Infectious Diseases · grant
Many HIV vaccine candidates have failed clinical trials, as they were unable to elicit a potent and durable response to HIV viral challenge. Broadly neutralizing antibodies (bnAbs) have been identified in a number of HIV+ individuals with w…
Posted May 21, 2026
Nonviral delivery techniques for in vivo prime editing
US National Heart Lung and Blood Institute · grant
Gene editing is a promising strategy for treating or even permanently curing genetic diseases. In particular, a new technique called prime editing has the potential to make small targeted insertions, deletions, and substitutions with very h…
Posted May 21, 2026
Nucleic Acids Sequencing Core
US · IL NIH RePORTER · grant
GENETICS AND GENOMICS CORE FACILITY (WestCore) OF SD BRIN (RESEARCH) Summary/Abstract SD BRIN has made significant strides in building critical infrastructure to meet the needs of biomedical researchers in South Dakota. From 2004 to 201…
Posted May 21, 2026
Synthesis and Biochemical Evaluation of Ruthenium Compounds
US National Institute of General Medical Sciences · grant
Project Summary Transition metal compounds have been used as therapeutic agents. However, treatment with these compounds, for example cisplatin, can lead to drug resistance and poor efficacy. Ruthenium has been studied as an alternative to…
Posted May 21, 2026
Understanding fertility trends in a cohesive high-fertility population within a low-fertility environment
US · IL NIH · NAICS 541720 · grant
Project Summary Western populations collectively responded to historically contingent, society-wide developments in the 19th and 20th centuries by reducing births to record-low levels. However, a minority of Westerners, largely ethnic secta…
Posted May 21, 2026
Development and testing of RSV vaccines using a computational framework of virus-host interaction
US · IL NIH · NAICS 541714 · grant
Respiratory Syncytial Virus (RSV) is the second leading cause of hospitalization in children worldwide and has been increasing appreciated as a cause of hospitalization and death in the elderly. Recent studies have shown that polyvalent vac…
Posted May 21, 2026
US Ten Day Seminar on the Epidemiology and Prevention of Cardiovascular Diseases and Stroke
US · IL National Heart, Lung, and Blood Institute (NHLBI) · grant
ABSTRACT This proposal requests sponsorship for the 49th U.S. Ten-Day Seminar. Given the burden of cardiovascular diseases (CVD) and stroke, it is highly appropriate to conduct professional training on epidemiology and prevention. The goals…
Posted May 21, 2026
Research and Mentoring in the Clinical Epidemiology and Health Disparities of Cardiovascular Diseases and Hypertension
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Cardiovascular disease affects nearly half of all American adults. Achieving cardiovascular health is associated with lower mortality and morbidity, but modifying and adhering to health behaviors such as diet and other healt…
Posted May 21, 2026
The effects of synaptically released zinc on neuronal processing and brain function
US · IL NIH · grant
Project Abstract Many regions of the brain including the cortex, hippocampus, basal ganglia, and limbic structures are highly enriched with synaptic zinc. Synaptic zinc (as Zn2+) is loaded into presynaptic vesicles by zinc transporter 3 (Zn…
Posted May 21, 2026
Linking State Medicaid and Congenital Heart Surgical Registry Data: Building Capacity to Assess Disparities in Longitudinal Outcomes and Value for Children with Congenital Heart Disease
US National Heart Lung and Blood Institute · grant
Congenital heart defects are the most common birth defects managed in the United States, affecting 1% of live births. Survivors often describe significant, chronic disease. Yet, limited longitudinal data exist. Further, income and other dem…
Posted May 21, 2026
CLINICAL TRIALS MONITORING SERVICE
US · IL National Cancer Institute (NCI) · grant
This is a Research and Development Support contract. The purpose of this acquisition is to assist the NCI in fulfilling its responsibilities to the Food and Drug Administration (FDA) and Department of Health and Human Services (DHHS) regul…
Posted May 21, 2026
CLINICAL TRIALS MONITORING SERVICE_ Moonshot support
US · IL National Cancer Institute (NCI), National Institutes of Health (NIH) · NAICS 541715 · grant
This is a Research and Development Support contract. The purpose of this acquisition is to assist the NCI in fulfilling its responsibilities to the Food and Drug Administration (FDA) and Department of Health and Human Services (DHHS) regula…
Posted May 21, 2026
Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer
US · IL NIH · grant
Project Summary Metastatic disease is the primary cause of cancer morbidity and mortality, resulting in >10 million deaths worldwide in 2020. Despite recent advances in our knowledge of metastatic tumor development, there is a critical nee…
Posted May 21, 2026