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Showing 25 / 21760 · page 41/871
Targeting Endosomal dysfunction as a new source of biomarkers for Alzheimer's disease
US National Institute on Aging · grant
Endosomal dysfunction is a well-accepted cell biological feature in Alzheimer’s disease (AD). However, biomarkers reflecting endosomal traffic defects are still lacking. Current imaging and cerebrospinal fluid (CSF) AD biomarkers focus prim…
Posted May 21, 2026
Gut pathogen virulence and its therapeutic modulation during surgical injury
US · IL NIH · grant
1 We demonstrated in both mice and critically ill humans, that following surgical injury/infection, the gut 2 microbiota collapse in structure, membership and function (i.e., production of health-relevant metabolites) such 3 that both imm…
Posted May 21, 2026
In situ destruction of halogenated Superfund contaminants with biological radical reactions
US · IL NIH · NAICS 541714 · grant
PROJECT 3: SUMMARY/ABSTRACT Highly halogenated compounds include recently recognized pollutants such as per- and polyfluorinated alkyl substances (PFAS) as well as legacy contaminants, such as chlorinated solvents, polychlorinated biphenyls…
Posted May 21, 2026
The Developmental Transition of Neural Stem Cell Niches in the Human Brain
US National Institute of Neurological Disorders and Stroke · grant
Project Summary Our earlier work identified the neural stem cells (NSC) and intermediate progenitors that generate new neurons and glial cells in the adult mouse brain. These NSCs are regionally specified to produce unique sets of inhibitor…
Posted May 21, 2026
Synaptic mechanisms underlying reward seeking and compulsive drug use
US National Institute on Alcohol Abuse and Alcoholism · grant
Project title: “Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males ” The brain’s reward circuitry remains sensitive to experience throughout early life an…
Posted May 21, 2026
Section on Neurobiology of Compulsive Behaviors
US National Institute of Mental Health · grant
Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males: The brain’s reward circuitry remains sensitive to experience throughout early life and into adulthood,…
Posted May 21, 2026
Functional Mechanism of Neural Control in Post-Concussion Convergence Insufficiency
US National Eye Institute · grant
Project Summary/Abstract: During the past 6 years, our study team investigated the neural mechanism of typically-occurring convergence insufficiency (TYP-CI), the most common binocular vision disorder in children and young adults (3.4% to 1…
Posted May 21, 2026
Project 4: Pyrolytic conversion of PAHs in contaminated sediments into char to eliminate toxicity and enhance soil fertility
US · IL NIH · NAICS 541715 · grant
Project Summary There is a pressing need for more reliable and cost-effective remediation of contaminated soils and sediments at Superfund sites to mitigate exposure and protect public health. This project will develop a sustainable thermal…
Posted May 21, 2026
Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model
US · CA · Los Angeles National Institutes of Health (NIH) · grant
PROJECT SUMMARY Alphaviruses are mosquito-borne viruses that can cause arthritis and fatal encephalitis in humans with no approved therapeutics. Encephalitic alphaviruses, like Sindbis (SINV) and chikungunya (CHIKV) viruses, must cross the …
Posted May 21, 2026
Rise to the Challenge Bridge to Health Informatics and Bioinformatics
US National Institute of General Medical Sciences · grant
The mission of the Rise to the Challenge Bridge to Health Informatics and Bioinformatics program is to continue providing the skills and resources for El Paso Community College (EPCC) students to successfully transfer to the University of T…
Posted May 21, 2026
How cell maturation is regulated by circadian and metabolic rhythms
US · IL National Institute of General Medical Sciences · grant
Project Summary/Abstract The overall goal of my research program is to mechanistically understand how circadian and metabolic rhythms shape how fully differentiated cells become functionally specialized, or “mature”. Cycles in energy availa…
Posted May 21, 2026
Mitochondrial influences on blood brain barrier function and neuropsychiatric illness
US · IL NIH · grant
Neuropsychiatric disorders are increasingly associated with neuroinflammatory processes. The blood-brain barrier (BBB) is a critical modulator of peripheral inflammatory influences on brain development and function. PIs Jorge Alvarez, a neu…
Posted May 21, 2026
Role of the brain-immune axis in neuropsychiatric disease
US · IL NIH · grant
The study of brain-immune interactions has contributed to a paradigm shift in the understanding of the pathophysiology of mental disorders and has provided new insights into their prevention and treatment. Notably, the blood-brain barrier (…
Posted May 21, 2026
A Dietary Intervention to Improve Glucose Tolerance in Adults with Cystic Fibrosis
US · IL NIH · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Successes in therapies for individuals with cystic fibrosis (CF) have exponentially improved survival in this population. There is now a critical need for better understanding of how to promote optimal long-term hea…
Posted May 21, 2026
Core 2, NLB
US · IL NIH · grant
Posted May 21, 2026
Par-4 Regulation of Actomyosin Contractility as a Tumor Suppressive Mechanism in Breast Cancer
US · IL NIH · grant
Project Summary/Abstract Tumor progression – including resistance to therapy, metastasis, and recurrence – is responsible for the majority of cancer deaths. Understanding how cancer cells survive treatment, spread to distant sites, persist …
Posted May 21, 2026
NRF2 suppression of inflammatory signaling and its role in tumor progression
US · IL NIH · grant
Project Summary/Abstract Tumor metastasis is responsible for the vast majority of deaths from epithelial cancers, including breast cancer. Understanding how cancer cells spread to distant sites, persist as dormant disseminated tumor cells …
Posted May 21, 2026
Development of Synaptic Inputs on Spinal Interneurons
US · IL NIH · grant
PROJECT SUMMARY (30-lines) Movement depends on patterned spinal cord motor output necessary for coordinated muscle actions. This in turn, depends on spinal interneuron microcircuits that modulate motoneuron recruitment and firing. The recen…
Posted May 21, 2026
Characterizing the formation and maintenance of drug-biased beliefs in opioid use disorder
US · IL NIH RePORTER · NAICS 541715 · grant
PROJECT SUMMARY/ABSTRACT Despite psychoeducational efforts highlighting consequences of opioid use, relapse remains common for individuals with opioid use disorder (OUD). This clinical observation indicates a need for better understanding h…
Posted May 21, 2026
Barriers and Facilitators for Delivery of Guideline-Concordant Care for Adolescents and Young Adults with Ewing Sarcoma and Osteosarcoma
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Roughly 90,000 adolescents and young adults (AYAs: 15–39) are diagnosed with cancer in the United States each year. Disparities in cancer mortality exist among AYAs with Ewing sarcoma (EWS) and osteosarcoma (OS), …
Posted May 21, 2026
The Role of CD4+ Memory T cell Subtypes in Periodontal Disease Recurrence
US National Institute of Dental and Craniofacial Research · grant
Project Summary The recurrence of periodontal disease (PD) is a poorly immunologically defined or therapeutically targeted clinical challenge. Uncovering the homeostatic and pathogenic potential of long-term immune cells in periodontal tiss…
Posted May 21, 2026
Mechanisms of Immediate Non-IgE-mediated Drug Hypersensitivity Reactions (MIND-HR)
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Although IgE-mediated HSRs are the most feared, most drug HSRs are non-IgE-mediated and often require only dosage and administration adjustments rather than complete drug avoidance. Clinical similarities between IgE…
Posted May 21, 2026
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathy
US · IL NIH · grant
PROJECT SUMMARY / ABSTRACT Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a complex inherited disorder of the heart produced by mutation in proteins of the desmosome, such as plakophilin-2 (PKP2). Cardiac arrhythmias, and potenti…
Posted May 21, 2026
Identifying neurocognitive correlates of reading impacted by adversity exposure
US · IL NIH · grant
PROJECT ABSTRACT/SUMMARY Reading is a developmental process and a core component of education that depends on the acquisition, integrity, and processing efficiency of fundamental text-based, linguistic, and neurocognitive processes refined …
Posted May 21, 2026
Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?
US National Institute on Minority Health and Health Disparities · grant
Modified Abstract Section This study represents a timely investigation that addresses differences in type 2 diabetes (T2DM) care using the most up-to-date encounter data post 2016 (ICD switch). T2DM is a burdensome chronic condition that d…
Posted May 21, 2026