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Showing 25 / 21760 · page 46/871
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect in which the left side of the heart is underdeveloped, with structural malformations to the ascending aorta, aortic/mitral valves, and a cha…
Posted May 21, 2026
The non-canonical Collagen I-DDR1 signaling regulating protein synthesis during metastasis
US · IL NIH · grant
PROJECT SUMMARY The activation of signaling tumor cells via the tumor micrenvironment (TME) to undergo metastasis in bladder cancer is understudied. Clinically, increased Col I deposition correlates with bladder cancer progression (i.e. inc…
Posted May 21, 2026
Staphylococcus aureus Survival During Nutrient Restriction and Suppression of Host Immunity.
US National Institute of Allergy and Infectious Diseases · grant
Project Summary Staphylococcus aureus is a leading cause of nosocomial infection in the United States and is a predominant pathogen in communities. S. aureus survives during infection by subverting immune defenses and adapting to host-impos…
Posted May 21, 2026
Bacterial lipases and adaptation to the host lipid environment
US National Institute of Allergy and Infectious Diseases · grant
Project Summary The host lipid environment is a well-described barrier to bacterial infection at several sites including the skin, lung, and upper airways. In addition, both bacterial and host lipids serve as signals that promote inflammati…
Posted May 21, 2026
Bacterial cell wall remodeling, innate immunity, and pathogenesis
US · IL NIH · grant
Project Summary Infections caused by Staphylococcus aureus remain one of the most significant burdens to human health with ~750,000 associated deaths worldwide reported in 2019; a third of which were directly attributed to antimicrobial res…
Posted May 21, 2026
Benefits and harms of activating ATF6 in beta cells
US · IL NIH · grant
ABSTRACT Pancreatic beta cell insulin production is the critical lynchpin that determines diabetes resistance or susceptibility. ER stress is one cause of beta cell dysfunction and failure, not only in T2D but also in T1D and some forms of …
Posted May 21, 2026
Research Training in Endocrinology and Metabolism
US · IL NIH · NAICS 611310 · grant
PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface…
Posted May 21, 2026
Neuronal mechanisms of image processing in the early visual pathway
US · IL National Institutes of Health (NIH) · grant
PROJECT SUMMARY Images captured by our eyes are processed in the retina by separate ON and OFF pathways that signal light and dark stimuli in visual scenes. The traditional thinking is that the two pathways converge in visual cortex and the…
Posted May 21, 2026
Pediatric Acute Liver Failure Immune Response Network (PALF IRN): Treatment for Immune Mediated Pathophysiology (TRIUMPH)
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Project Summary Pediatric Acute Liver Failure (PALF) is a rare, devastating condition that affects an estimated 250 children per year in North America, causing death in approximately 15% and the need for liver transplantation (LT) in an add…
Posted May 21, 2026
Targeting regenerative reprogramming in colorectal cancer
US · NY NIH · grant
ABSTRACT Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to treatment-refractory tumors. The expanded use of sequencing tools have led to the recognition that refractory tumors ofte…
Posted May 21, 2026
Teachers and Students for Community-Oriented Research and Education: Linking Industry Partners, Faculty, and Teachers (TSCORE LIFT)
US National Institute of General Medical Sciences · grant
21st-century changes in healthcare have rapidly outpaced advancements in science education, leaving many high school students without access to high-quality, experiential science learning essential for preparing future health professionals.…
Posted May 21, 2026
Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use
US · IL NIH · grant
PROJECT ABSTRACT Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use of opioid substances, including prescribed pharmaceuticals (such as oxycodone) and illegal agents (such as heroin). It…
Posted May 21, 2026
Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment
US · IL NIH · grant
ABSTRACT Maternal immune activation (MIA) during prenatal or postnatal development significantly increases the risk for offspring neurodevelopmental disorders (NDDs) later in life. Growing evidence suggest that regardless of the MIA stimuli…
Posted May 21, 2026
Absolute Brain Thermography using Multinuclear MRI
US · IL NIH RePORTER · grant
PROJECT SUMMARY Stroke is the leading cause of disability, the second leading cause of dementia, and the second leading cause of death worldwide, affecting nearly 800,000 patients per annum in the U.S. alone. Cerebrovascular ischemia is ra…
Posted May 21, 2026
Biological role and pharmacology of EXPERA family proteins and their effect onsterol homeostasis
US National Institute of General Medical Sciences · grant
Abstract EXPERA are a family of membrane proteins that include sigma-2 receptor and TM6SF2, both of which play crucial yet understudied roles in cholesterol metabolism and disease. Sigma-2, an enigmatic membrane receptor implicated in cance…
Posted May 21, 2026
Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment
US National Institute on Drug Abuse · grant
PROJECT SUMMARY/ABSTRACT The candidate’s long-term goal is to shift his research focus from examining neural correlates of individual differences in adolescent substance use disorders toward neurobiological predictors of individual treatme…
Posted May 21, 2026
Novel Spatial-Motor Approaches Targeting Post-Stroke Spatial Neglect and Gait Deficits
US · IL NIH RePORTER · grant
PROJECT SUMMARY/ABSTRACT Aiming spatial neglect (SN) is a sub-type of SN that is a dysfunction in initiation/execution of motor–intentional behavior. SN components such as directional hypokinesia, turning behavior, weight-bearing asymmetry,…
Posted May 21, 2026
Caspase-1 Activation by the Inflammasomes
US National Institute of Arthritis and Musculoskeletal and Skin Diseases · grant
Inflammasomes are multi-protein complexes that assemble to activate caspase-1 in response to tissue damage and infection by microbial or viral pathogens. Once activated, caspase-1 processes the inactive proforms of interleukin-1β (IL-1β) an…
Posted May 21, 2026
Investigating Novel HIV Reservoirs in the Pulmonary Vasculature
US National Institute of Allergy and Infectious Diseases · grant
PROJECT SUMMARY Infections with Human Immunodeficiency Virus (HIV) remain a major global public health concern. The HIV reservoirs are a leading reason for which HIV infection remains without a cure. HIV integrates its viral DNA into the ho…
Posted May 21, 2026
Role of HIV gp120 and Nef in Transcriptome Dysregulation and Pulmonary Vascular Remodeling
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY People living with HIV (PLWH) are at a significantly high risk of developing Pulmonary Hypertension (PH), which can lead to death by heart failure, even with the suppressive effects of antiretroviral therapy (ART). PH is ch…
Posted May 21, 2026
MI-SMART: Methods for Optimizing Multilevel Adaptive Implementation Strategies to Promote the Adoption of Effective SUD and HIV Services
US National Institute on Drug Abuse · grant
PROJECT SUMMARY: PROJECT 1 Evidence-based prevention, treatment, and recovery services for substance use disorders (SUDs) and HIV often fail to be implemented or sustained due to barriers at multiple levels, such as lack of time and skills …
Posted May 21, 2026
Dissecting enzyme function at scale using synergistic advances in microfluidics and genetic code expansion
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY. Noncanonical amino acids (ncAAs) have myriad valuable applications in the biochemical and biophysical sciences. Their site-specific incorporation into proteins of interest can directly install systematically perturbed resi…
Posted May 21, 2026
Defining the therapeutic efficacy, tolerogenic potential, and genotoxicity of liver-targeted AAV gene therapy for hemophilia A
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY: Gene therapy (GT) for the hemophilias is poised to fulfill the promise of a safe, affordable, lifelong correction following a single treatment. Yet clinical trials employing AAV vectors to treat adult hemophilia A (HA) pati…
Posted May 21, 2026
Using human liver tissue equivalents to optimize AAV-mediated GT and better define age-related clinical risks
US · IL NIH · NAICS 541714 · grant
PROJECT SUMMARY Gene therapy (GT) clinical trials using AAV vectors are poised to fulfill the promise of a safe, affordable, lifelong correction of bleeding disorders following a single treatment. Still, clinical trials using AAV vectors to…
Posted May 21, 2026
Targeted conditioning to maximize prenatal HSC engraftment for SCD
US · IL NIH · grant
PROJECT ABSTRACT: Treatment of genetic disorders by in utero transplantation (IUTx) has safely been performed for decades in humans. The first IUTx cure, in the US, used hematopoietic stem cells (HSC) and corrected a child with X-SCID. Sinc…
Posted May 21, 2026