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Showing 25 / 21760 · page 24/871
Genetically engineered mouse models to investigate the liposarcoma microenvironment
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Liposarcoma (LPS) is the most common type of soft tissue sarcoma. The most common subtypes are well- differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma which are characterized by genomic amplification o…
Posted May 21, 2026
Durability of memory T cell responses in melanoma
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Melanoma is the most lethal type of skin cancer. About 50% of patients with metastatic melanoma have a meaningful response to treatment with immunotherapy, of which some develop a durable response. Many patients wit…
Posted May 21, 2026
Core Vision Grant - Design & Fabrication
US National Eye Institute · grant
Abstract The Design and Fabrication Module supports vision research at New York University by providing an expert in CAD/CAM design and fabrication to assist vision researchers in designing custom equipment and managing fabrication at at NY…
Posted May 21, 2026
Neural Mechanisms of Vestibular Function
US · IL NIH · grant
PROJECT SUMMARY We investigate an important function of the vestibular system, and its multisensory properties, in spatial navigation, specifically head direction (HD) cells. HD cells encode directional heading like a compass and these prop…
Posted May 21, 2026
The role of an unusual variant nucleosome in Toxoplasma gondii life cycle
US National Institute of Allergy and Infectious Diseases · grant
Program Director/Principal Investigator (Last, First, Middle): Sergio Oscar Angel ABSTRACT The parasite Toxoplasma gondii has infected up to one-third of the world’s population and can cause spontaneous abortion, birth defects, neurologic …
Posted May 21, 2026
Conference Series on Aging in the Americas: United States and Mexico-Renewal
US · IL National Institutes of Health (NIH) · grant
Project Summary  Hispanic populations in the United States and Latin America will confront critical health issues in the 21st century. In the United States, poverty among older Hispanic individuals is twice as high as that for non-Hispanic …
Posted May 21, 2026
Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.
US · IL National Institute on Drug Abuse (NIDA) · grant
PROJECT SUMMARY/ABSTRACT The recent resurgence in cocaine use in the U.S. is a significant public health concern and there is an urgent need to address the long-standing absence of effective treatments for cocaine-use disorder (CUD). Highl…
Posted May 21, 2026
Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder
US · IL National Institute of Health · grant
Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of H…
Posted May 21, 2026
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET Study
US · IL NIH · grant
Abstract In seminal preclinical studies nearly 20 years ago, Robinson & Kolb [1, 2] demonstrated enduring changes in synaptic (dendritic spine) density in medial prefrontal cortex (mPFC) of rodents following behaviorally sensitizing regimen…
Posted May 21, 2026
South Dakota Pediatric Clinical Trials Network (SoDakPCTN)
US National Institutes of Health (NIH) · grant
PROJECT SUMMARY This proposal seeks to con�nue to build pediatric clinical trials capacity in South Dakota through the South Dakota Pediatric Clinical Trials Network. The Avera Health system and partners are ideally suited to conduct pediat…
Posted May 21, 2026
Training Component
US · IL NIH · grant
PROJECT SUMMARY The overall goal of the MARCH Training Component is to enhance knowledge and skills for investigators and community partners to conduct research and improve care for pregnant women to reduce the risk of pregnancy-associated …
Posted May 21, 2026
A 3D zebrafish microanatomical and gene expression atlas for disease modeling
US NIH Office of the Director · grant
Project Summary The zebrafish is a vertebrate model organism with significant genetic, cellular, and physiological similarities with humans. Its powerful genetic and imaging tools have allowed us to decipher gene function, embryonic develop…
Posted May 21, 2026
Ultrafast Biophysical Studies of Biomolecules at the NIH
US · IL NIH · grant
In 2024, we introduced a major update of the software used by the Bax group to control our home-built Icarus-I and Icarus-II pressure jump systems. This release was coded by Sean Fitch, a computer science undergraduate who offered his servi…
Posted May 21, 2026
Ultrafast Biophysical Studies of Biomolecules at the APS
US National Institute of Diabetes and Digestive and Kidney Diseases · grant
Our time-resolved x-ray studies of biomolecules have been pursued on the BioCARS beamline at the Advanced Photon Source (APS), which shut down operations in May 2023 to implement a major upgrade (APS-U) that aims to reduce significantly the…
Posted May 21, 2026
Evaluating Ghost Pipe (Monotropa uniflora) as a Potential Source of Novel Analgesic Compounds
US · IL NIH · grant
PROJECT SUMMARY/ABSTRACT Chronic pain is one of the most common reasons for seeking medical care, affecting 50 million Americans. While often treated with opioid pharmaceutical or surgical interventions, complementary traditional health app…
Posted May 21, 2026
Identifying patient subgroups and processes of care that cause outcome differences following ICU vs. ward triage among patients with acute respiratory failure and sepsis
US National Heart Lung and Blood Institute · grant
PROJECT SUMMARY Decisions to admit patients with acute respiratory failure (ARF) and sepsis (the most common and lethal cause of the acute respiratory distress syndrome) to intensive care units (ICUs) are highly variable across the US. And,…
Posted May 21, 2026
Hospital adaptation and resiliency for infected and uninfected patients during respiratory viral surge events: from seasonal influenza to COVID-19
US · PA NIH · grant
Project Summary / Abstract My long-term career goal is to become a leading independent investigator developing and evaluating surveillance, preparedness, and operations response strategies to combat the public health burdens from respirator…
Posted May 21, 2026
A Family-Based Digital Intervention to Address Early Substance Use Among Adolescents in Primary Care Settings
US National Institute on Drug Abuse · grant
This proposal seeks to develop and evaluate a novel tailored family-based videogame, FamilyBond (FamB), to prevent increases in substance misuse among mid-adolescents with early substance use in primary care settings. Over six million adole…
Posted May 21, 2026
The Impact of Positive Airway Pressure (PAP) Therapy on Myocardial Blood Flow in Adults with Obstructive Sleep Apnea at High-Risk of Cardiovascular Disease: The PAP-Flow Study
US National Heart Lung and Blood Institute · grant
ABSTRACT New and innovative approaches to studying modifiable mechanisms of heart failure are crucial. Heart failure impacts approximately 7 million adults in the United States and has a 5-year mortality rate of 42%. Obstructive sleep apnea…
Posted May 21, 2026
REACH Center Administrative Core
US · IL NIH · grant
PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core aims to promote relevant research through funding and coordination of the Developmental Core, Community Engagement Core, and Exposure Assessment Core. The Administrative Core …
Posted May 21, 2026
Cancer Prevention and Control Training Program
US National Cancer Institute · grant
We propose renewal of the University of Alabama at Birmingham (UAB) Cancer Prevention and Control Training Program T32 training grant. Our training program is the only one in the Deep South (Louisiana, Mississippi, Alabama, Georgia, South C…
Posted May 21, 2026
An integrated exercise and bladder training intervention to reduce falls in older women with urinary incontinence
US · IL NIH · grant
Project Summary/Abstract Urgency urinary incontinence (UUI) is a biomarker of falls risk and disproportionately affects older minority women living in urban communities. Over 50% of an estimated 10 million women age 70 and older with UUI wi…
Posted May 21, 2026
T cell Contributions to Neointima Formation in Pulmonary Hypertension
US National Heart Lung and Blood Institute · grant
Pulmonary Hypertension (PH) is a fatal disease where abnormal cells termed “neointima” progressively occlude the pulmonary arteries leading to debilitating right heart failure. PH pathology is characterized by perivascular inflammation, inc…
Posted May 21, 2026
Small-Molecule Covalent E6 Antagonists for Treatment of HPV Infection
US National Cancer Institute · grant
ABSTRACT “High-risk” human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, anogenital, and oropharyngeal epithelia. The E6 protein is esse…
Posted May 21, 2026
Development of multinuclear MRI for image guided therapy of glioma patients
US · IL NIH · grant
7. Project Summary/Abstract Gliomas have a low survival rate of 36% at five-years, half the average survival rate across all cancers according to the last SEER and CBTRUS reports. Malignant brain tumors cause on average 20 years of potentia…
Posted May 21, 2026